All About the Placebo Effect

  • What is the placebo effect? 
  • Can it really help conditions like migraines and depression?  
  • Placebo effect examples and case studies  

Chances are, you’ve probably heard about sugar pills or plain saline syringe injections appearing to help people with everything from cancer and fatigue to chronic pain. In this blog post, you’re going to find out everything there is to know about the famous placebo effect.   

What Is a Placebo Effect?   

When a person’s physical or mental health appears to improve after receiving a placebo or ‘dummy’ treatment, this is referred to as the placebo effect.  

 The term ‘placebo’ refers to a treatment that appears to be effective but is actually ineffective. A placebo may take the form of a sugar pill, an injection of water or salt water (saline), or even a phoney surgical procedure.  

 The placebo effect is triggered by the individual’s belief in the treatment’s benefit and expectation of feeling better rather than by the placebo’s characteristics.  

 Placebos are frequently used in clinical trials to help determine the true effect of a new treatment – both the positive and negative effects.  

Placebo vs. Placebo Effect  

It is important to understand that a “placebo” and the “placebo effect” are different. The phrase placebo refers to the inert substance itself, but the term placebo effect refers to any medication side effects that cannot be linked to the treatment itself.1 

True Stories 

Let’s look at a story, shall we? The Reddit user named NeoCoN7 experienced this very thing, although second-hand. In high school chemistry class, their teacher gave everyone a drop to taste (supposedly) pure alcohol. Ten minutes later, a large group of girls started to behave…, well, for lack of a better term, drunk. Giggly and swaying on their stools throughout the entire class. Just before the end of the lesson, their teacher revealed the truth, that the ‘alcohol’ was just pure water. Talk about second-hand embarrassment.   

 Intrigued? Here’s another one. Seventy-one-year-old Jim Pearce was in a wheelchair experiencing excruciating chronic back pain, for which he needed morphine for. Little did he know how much a little blue and white striped ‘pill’ would change his life. One tiny detail, though; the pill in question was nothing but ground rice—a placebo.   

 His response when asked about his pain? “I just woke up one morning, and I thought, hang about, I haven’t got a twinge in my back. And it’s been going from strength to strength.”  

Studies and Research on the Placebo Effect  

Migraines   

A 2014 study looked at how people thought about the world.  

Researchers looked at 66 participants on how the labelling of drugs made them more likely to get migraines. How the study was set up:  

During six different migraines, the people who took part were asked to take a pill to help. At these times, they were given something called Maxalt, which is used to treat migraines.  

The labelling of the pills changed a lot during the study. They could be called a placebo, Maxalt, or any other type of medicine (neutral).  

During a migraine, people were asked to rate how much pain they felt 30 minutes into the migraine, take their pill, and then rate how much pain they felt 2.5 hours later.  

Placebo, Maxalt, or a neutral pill label affected how much pain people said they felt. The following are the results of the test:  

As expected, Maxalt gave more relief than the placebo did. However, placebo pills were found to help more than a control group that didn’t get any treatment at all.  

It turned out labelling was important! People who took Maxalt and a placebo were asked to rate how much relief they felt based on their labels. People in both groups who took Maxalt pills had higher scores than people who took placebo pills.  

A placebo labelled as Maxalt gave the same amount of relief as one labelled as a placebo that was labelled as Maxalt.  

Depression   

A study published in 2015 examined the placebo effect in 35 individuals with depression. At the time of the study, participants were not taking any additional antidepressant medication. The study was designed as follows:  

Each subject was given a placebo pill. However, some were labelled as an antidepressant with a rapid onset of action (the active placebo), while others were labelled as a placebo (the inactive placebo). Each group was assigned to take the pills for a week.  

After the week was up, a PET scan was used to determine brain activity. The active placebo group received a placebo injection during the scan, explaining that it may improve their mood. No injections were given to the inactive placebo group.  

For another week, the two groups switched pill types. A second PET scan will be performed at the end of the week.  

Following that, all participants received ten weeks of antidepressant treatment.  

The researchers discovered that some individuals experienced the placebo effect, which affected their brain activity and antidepressant response. The findings were as follows:  

When people were given the active placebo, depression symptoms were reduced.  

Taking the active placebo (including the placebo injection) increased brain activity in areas associated with emotion and stress regulation, as measured by PET scans.  

Individuals who had increased brain activity in this area frequently responded better to the antidepressants used at the end of the research.  

Fatigue As an After Effect from Cancer  

Fatigue may persist as a symptom for some cancer survivors. In 74 cancer survivors with fatigue, a 2018 study tested the effects of a placebo versus standard treatment. The study was carried out in the following way:  

Participants got either a tablet labelled as a placebo or their usual treatment for three weeks. After three weeks, those taking the placebo pills discontinued use. Meanwhile, patients getting standard care chose to take the placebo pills for three weeks.  

Following the study’s conclusion, the researchers found that the placebo affected both groups of participants despite its labelling as a placebo. The following were the findings:  

After three weeks, those getting a placebo reported improved symptoms compared to those receiving standard treatment. Additionally, they reported ongoing improvement in symptoms three weeks following discontinuance.  

Individuals receiving standard treatment who chose to take the placebo tablet for three weeks likewise reported improved fatigue symptoms after three weeks.2  

Factors That Increase the Likelihood of The Placebo Effect  

Expectations And Attitude  

Kind of like a self-fulfilling prophecy, expectations, or what we think will happen, have been found to play a key role in the placebo effect. People who are very excited about the treatment and think it will work may be more likely to have a placebo effect.   

It can even affect how a patient responds to treatment if the prescribing doctor is psyched about it. Patients may be more likely to benefit from taking a drug if their doctor is sure that it will work. Verbal, behavioural, and social clues can help people think that the medication will work.  

Genetics May Be at Play  

Genes may also impact how people respond to placebos. Some people respond better to placebos than others. One study indicated that those with a high-dopamine gene variant are more susceptible to the placebo effect than those with a low-dopamine variant. The high-dopamine variant of this gene also increases pain perception and reward-seeking.  

Hormones in Action  

Taking the placebo may have caused endorphin release. Endorphins are produced naturally by the brain. Using brain scans, researchers showed that both the placebo and treatment groups stimulated areas that contain numerous opiate receptors.  

The Polar Opposite of Placebo Effect  

The “nocebo effect,” on the other hand, refers to the phenomenon in which people respond to a placebo by experiencing an increase in symptoms or adverse effects. A patient may complain of headaches, nausea, or dizziness after taking a placebo.3  

Key Takeaways  

Even though the placebo effect can significantly impact how you feel, it’s important to bear in mind that it isn’t a cure-all.  

It is unethical for healthcare providers to use placebos in real life without telling their patients. This reduces or eliminates the placebo effect. However, scientists can better understand how medicines affect patients and if newer and more innovative medications and treatment approaches are safe and successful by using placebos in studies, during which they do not have to inform the subject.  

We hope you enjoyed this blog post and found it informative. What’s your experience with placebo effects working? Share them down in the comments section below. Thank you!  

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  70. {Tôi đã khá hài lòng để tìm thấy trang web tuyệt vời này. Tôi cần cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thưởng thức từng một chút nó và tôi đã đã lưu vào mục ưa thích để xem điều mới trên trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để tìm thấy một người mà thực sự hiểu họ là gì thảo luận trên web. Bạn chắc chắn biết cách đưa một rắc rối ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa nên xem điều này và hiểu khía cạnh này của. Thật ngạc nhiên bạn không nổi tiếng hơn vì bạn chắc chắn nhất sở hữu món quà.|Rất hay bài viết trên blog. Tôi chắc chắn đánh giá cao trang web này. Tiếp tục làm tốt!|Thật khó đến những người có kinh nghiệm trong chủ đề cụ thể này, nhưng bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên tham gia một cuộc thi dành cho một blog trên mạng tốt nhất. Tôi sẽ Rất khuyến nghị blog này!|Một cuộc thảo luận thú vị chắc chắn đáng giá bình luận. Tôi nghĩ rằng bạn cần xuất bản thêm về vấn đề này, nó có thể không là một điều cấm kỵ chủ đề nhưng thường xuyên mọi người không thảo luận những chủ đề những điều này. Đến phần tiếp theo! Chúc mừng!|Xin chào! Tôi chỉ muốn đề nghị rất to cho thông tin xuất sắc bạn có ở đây trên bài đăng này. Tôi sẽ là trở lại blog của bạn để biết thêm thông tin sớm nhất.|Sau khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp hộp kiểm -Thông báo cho tôi khi có bình luận mới- và từ bây giờ bất cứ khi nào có bình luận được thêm vào tôi nhận được bốn email có cùng nội dung. Có một phương pháp dễ dàng bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn.|Lần sau Tôi đọc một blog, Tôi hy vọng rằng nó không thất bại nhiều như bài này. Ý tôi là, Vâng, đó là sự lựa chọn của tôi để đọc hết, nhưng tôi thực sự tin có lẽ có điều gì đó thú vị để nói về. Tất cả những gì tôi nghe được là một loạt khóc lóc về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi hoàn toàn tin trang web này cần nhiều hơn nữa sự chú ý.

  71. {Tôi đã háo hức để tìm thấy trang web tuyệt vời này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thích từng một phần nó và tôi cũng đã đánh dấu để xem thông tin mới trên trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một người mà thực sự biết họ là gì thảo luận trực tuyến. Bạn thực sự nhận ra cách đưa một vấn đề ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa nên đọc điều này và hiểu khía cạnh này câu chuyện của bạn. Tôi đã ngạc nhiên bạn không nổi tiếng hơn vì bạn chắc chắn sở hữu món quà.|Rất hay bài đăng. Tôi chắc chắn đánh giá cao trang web này. Cảm ơn!|Thật gần như không thể tìm thấy những người có hiểu biết sâu rộng về điều này, nhưng bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên là một phần của một cuộc thi dành cho một trang web trên internet tốt nhất. Tôi sẽ Rất khuyến nghị blog này!|Một động lực đáng giá bình luận. Tôi tin rằng bạn nên viết thêm về vấn đề này, nó có thể không là một điều cấm kỵ chủ đề nhưng thường xuyên mọi người không nói về chủ đề những điều này. Đến phần tiếp theo! Cảm ơn rất nhiều!|Xin chào! Tôi chỉ muốn đề nghị rất to cho thông tin xuất sắc bạn có ở đây trên bài đăng này. Tôi sẽ là quay lại trang web của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu bình luận tôi có vẻ như đã nhấp hộp kiểm -Thông báo cho tôi khi có bình luận mới- và từ bây giờ bất cứ khi nào có bình luận được thêm vào tôi nhận được 4 email có cùng nội dung. Phải có một phương tiện bạn có thể xóa tôi khỏi dịch vụ đó không? Kudos.|Lần sau Tôi đọc một blog, Tôi hy vọng rằng nó không thất bại nhiều như bài này. Rốt cuộc, Tôi biết điều đó là sự lựa chọn của tôi để đọc hết, tuy nhiên tôi thực sự nghĩ bạn sẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt rên rỉ về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi hoàn toàn tin trang web tuyệt vời này cần nhiều hơn nữa sự chú ý.

  72. {Tôi đã hạnh phúc hơn cả vui khám phá trang web này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thưởng thức từng một chút nó và tôi đã đã đánh dấu trang để xem những thứ mới trong trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để tìm thấy một người mà thực sự biết họ là gì đang nói về trên internet. Bạn chắc chắn nhận ra cách đưa một rắc rối ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa cần xem điều này và hiểu khía cạnh này của. Tôi không thể tin bạn không nổi tiếng hơn vì bạn chắc chắn sở hữu món quà.|Rất hay bài viết trên blog. Tôi hoàn toàn đánh giá cao trang web này. Tiếp tục viết!|Thật gần như không thể tìm thấy những người có kinh nghiệm trong chủ đề cụ thể này, tuy nhiên, bạn có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn cần tham gia một cuộc thi dành cho một trang web trên internet hữu ích nhất. Tôi sẽ khuyến nghị trang web này!|Một hấp dẫn chắc chắn đáng giá bình luận. Tôi tin rằng bạn nên xuất bản thêm về chủ đề này, nó có thể không là một điều cấm kỵ vấn đề nhưng điển hình mọi người không nói về vấn đề những điều này. Đến phần tiếp theo! Chúc mọi điều tốt đẹp nhất!|Chào buổi sáng! Tôi chỉ muốn cho bạn một rất cho thông tin xuất sắc bạn có ngay tại đây trên bài đăng này. Tôi sẽ là trở lại trang web của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu bình luận tôi có vẻ như đã nhấp vào hộp kiểm -Thông báo cho tôi khi có bình luận mới- và từ bây giờ mỗi lần được thêm vào tôi nhận được bốn email có cùng nội dung. Có lẽ có một cách bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn rất nhiều.|Lần sau nữa Tôi đọc một blog, Tôi hy vọng rằng nó không làm tôi thất vọng nhiều như bài này. Rốt cuộc, Vâng, đó là sự lựa chọn của tôi để đọc hết, nhưng tôi thực sự nghĩ có lẽ có điều gì đó hữu ích để nói. Tất cả những gì tôi nghe được là một loạt phàn nàn về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi thành thật nghĩ trang web này cần nhiều hơn nữa sự chú ý.

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  74. {Tôi đã cực kỳ hài lòng để tìm thấy trang web tuyệt vời này. Tôi muốn cảm ơn bạn {vì đã|dành thời gian cho|chỉ vì điều này|vì điều này|cho bài đọc tuyệt vời này!! Tôi chắc chắn thích từng một chút nó và tôi cũng đã đánh dấu để xem những thứ mới trên trang web của bạn.|Tôi có thể chỉ nói rằng thật thoải mái để khám phá một người mà thực sự hiểu họ là gì thảo luận trực tuyến. Bạn chắc chắn biết cách đưa một rắc rối ra ánh sáng và làm cho nó trở nên quan trọng. Nhiều người hơn nữa phải đọc điều này và hiểu khía cạnh này của. Tôi đã ngạc nhiên bạn không nổi tiếng hơn cho rằng bạn chắc chắn có món quà.|Xuất sắc bài đăng. Tôi chắc chắn đánh giá cao trang web này. Tiếp tục làm tốt!|Thật khó đến những người hiểu biết về điều này, tuy nhiên, bạn nghe có vẻ bạn biết mình đang nói gì! Cảm ơn|Bạn nên tham gia một cuộc thi dành cho một trang web trên web có chất lượng cao nhất. Tôi chắc chắn sẽ khuyến nghị blog này!|Một động lực đáng giá bình luận. Không còn nghi ngờ gì nữa rằng bạn cần xuất bản thêm về chủ đề này, nó có thể không là một điều cấm kỵ chủ đề nhưng thường xuyên mọi người không thảo luận vấn đề những điều này. Đến phần tiếp theo! Trân trọng!|Xin chào! Tôi chỉ muốn đề nghị rất cho thông tin xuất sắc bạn có ngay tại đây trên bài đăng này. Tôi sẽ là trở lại trang web của bạn để biết thêm thông tin sớm nhất.|Khi tôi ban đầu để lại bình luận tôi có vẻ như đã nhấp vào hộp kiểm -Thông báo cho tôi khi có bình luận mới- và từ bây giờ mỗi lần được thêm vào tôi nhận được bốn email có cùng nội dung. Phải có một cách bạn có thể xóa tôi khỏi dịch vụ đó không? Cảm ơn.|Lần sau nữa Tôi đọc một blog, Hy vọng rằng nó không thất bại nhiều như bài này. Rốt cuộc, Vâng, đó là sự lựa chọn của tôi để đọc hết, nhưng tôi thực sự nghĩ có lẽ có điều gì đó hữu ích để nói về. Tất cả những gì tôi nghe được là một loạt tiếng rên rỉ về điều gì đó mà bạn có thể sửa nếu bạn không quá bận tìm kiếm sự chú ý.|Đúng với bài viết này, tôi nghiêm túc nghĩ trang web này cần nhiều hơn nữa sự chú ý.

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  255. The following time I read a blog, I hope that it doesnt disappoint me as a lot as this one. I mean, I do know it was my option to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you would fix should you werent too busy in search of attention.

  256. Your style is so unique compared to other people I have read stuff from. I appreciate you for posting when you’ve got the opportunity, Guess I will just book mark this blog.

  257. An outstanding share! I’ve just forwarded this onto a coworker who had been conducting a little homework on this. And he actually ordered me breakfast simply because I discovered it for him… lol. So allow me to reword this…. Thank YOU for the meal!! But yeah, thanx for spending some time to talk about this subject here on your blog.

  258. Having read this I thought it was really informative. I appreciate you spending some time and energy to put this article together. I once again find myself personally spending a significant amount of time both reading and posting comments. But so what, it was still worthwhile!

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